2. Signaling Pathways
  3. Immunology/Inflammation
    Vitamin D Related/Nuclear Receptor
  4. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor

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Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13693S2
    Mometasone furoate-13C,d6
    		Agonist
    Mometasone furoate-13C,d6 (Sch32088-13C,d6) is 13C-labeled Mometasone furoate (HY-13693).
    Mometasone furoate-<sup>13</sup>C,d<sub>6</sub>
  • HY-132269R
    Isoflupredone (Standard)
    		Ligand
    Isoflupredone (Standard) is the analytical standard of Isoflupredone. This product is intended for research and analytical applications. Isoflupredone belongs to the class of corticosteroids and exerts its effect by binding to glucocorticoid and mineralocorticoid receptors of animals, such as horses. Isoflupredone can be used in wide range of conditions, such as infection and inflammatory diseases.
    Isoflupredone (Standard)
  • HY-W071581
    Glucocorticoid receptor activator 1
    		Activator
    Glucocorticoid receptor activator 1 (compound A) is a phenyl aziridine precursor and an activator of the glucocorticoid receptor (GR). Glucocorticoid receptor activator 1 down-modulates TNF-induced pro-inflammatory gene expression by activating GR and can be utilized in inflammation research.
    Glucocorticoid receptor activator 1
  • HY-77839R
    Cortodoxone (Standard)
    		Antagonist
    Cortodoxone (Standard) is the analytical standard of Cortodoxone. This product is intended for research and analytical applications. Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation.
    Cortodoxone (Standard)
  • HY-116691R
    Hydrocortisone aceponate (Standard)
    		Agonist
    Hydrocortisone aceponate (Standard) is the analytical standard of Hydrocortisone aceponate. This product is intended for research and analytical applications. Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is a potent topical glucocorticoid. Hydrocortisone aceponate can be used for various dermatoses research.
    Hydrocortisone aceponate (Standard)
  • HY-125922
    (22R)-Budesonide
    		Agonist
    (22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity.
    (22R)-Budesonide
  • HY-A0158R
    Diflorasone (Standard)
    		Agonist
    Diflorasone (Standard) is the analytical standard of Diflorasone. This product is intended for research and analytical applications. Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis.
    Diflorasone (Standard)
  • HY-107015A
    Prednisolone metazoate sodium
    		Agonist
    Prednisolone metazoate sodium (ATL 2502) can be used for study of inflammatory bowel disease, ulcerative colitis, and GI disorders.
    Prednisolone metazoate sodium
  • HY-U00103R
    Triamcinolone hexacetonide (Standard)
    Triamcinolone hexacetonide (Standard) is the analytical standard of Triamcinolone hexacetonide. This product is intended for research and analytical applications. Triamcinolone hexacetonide is a commonly used long-acting steroids in treatment of subacute and chronic inflammatory joint diseases.
    Triamcinolone hexacetonide (Standard)
  • HY-400878
    Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal
    		Agonist 99.86%
    Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal, a glucocorticoid receptor agonist, is a drug-linker conjugate for ADC. Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal can be used to synthesize the anti-CD40 antibody agent conjugates (WO2019106608A1; example 9).
    Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal
  • HY-107939R
    Paramethasone Acetate (Standard)
    Paramethasone Acetate (Standard) is the analytical standard of Paramethasone Acetate. This product is intended for research and analytical applications. Paramethasone acetate is a synthetic glucocorticoid, and shows anti-inflammatory and immunosuppressant activities.
    Paramethasone Acetate (Standard)
  • HY-B1540R
    Beclometasone (Standard)
    		Agonist
    Beclometasone (Standard) is the analytical standard of Beclometasone. This product is intended for research and analytical applications. Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.
    Beclometasone (Standard)
  • HY-B0243R
    Meprednisone (Standard)
    		Agonist
    Meprednisone (Standard) is the analytical standard of Meprednisone. This product is intended for research and analytical applications. 0
    Meprednisone (Standard)
  • HY-19814
    Toripristone
    		Inhibitor
    Toripristone (RU-40555) is a cortisol receptor inhibitor. Toripristone combined with clarithromycin can increase the antibacterial activity of Mycobacterium avium complex infection.
    Toripristone
  • HY-W749404
    Clobetasone 17-Propionate
    		Activator
    Clobetasone propionate is a corticosteroid. Formulations containing clobetasol propionate have been used in the treatment of eczema, psoriasis, and lupus.
    Clobetasone 17-Propionate
  • HY-B0248R
    Desonide (Standard)
    		Inhibitor
    Desonide (Standard) is the analytical standard of Desonide. This product is intended for research and analytical applications. Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on glucocorticoid receptors.
    Desonide (Standard)
  • HY-137197
    6β-Hydroxy dexamethasone
    		Control
    6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid Dexamethasone (HY-14648).
    6β-Hydroxy dexamethasone
  • HY-N14422
    Collismycin B
    		Inhibitor
    Collismycin B is a potent dexamethasone-glucocorticoid receptor inhibitor with an IC50 value of 10 µM. Collismycin B shows antimicrobial activity. Collismycin B shows cytotoxicity.
    Collismycin B
  • HY-B0214S1
    Prednisone-d7
    		Agonist
    Prednisone-d7 (Dehydrocortisone-d7) is deuterium labeled Prednisone. Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus.
    Prednisone-d<sub>7</sub>
  • HY-B1365R
    Prednicarbate (Standard)
    		Agonist
    Prednicarbate (Standard) is the analytical standard of Prednicarbate. This product is intended for research and analytical applications. Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis.
    Prednicarbate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity